Top 5 Types Of Genetic Skin Disorders

By on August 5, 2013

Genetic Skin DisordersMany skin conditions are genetic, which are generally inherited from parents and develop during the initial stages of reproduction. These types of disorders occur from a sporadic change in the DNA of a gene.

Genetic skin disorders can present from infancy to adulthood. People who have this condition may experience a variety of symptoms such as tight skin, very dry skin, blistering and abnormal skin texture.

Genetic skin diseases are often known as genodermatoses. There are various types of genetic skin disorders such as epidermolysis bullosa, ichthyoses, harlequin ichthyosis, Incontinent pigmenti, Lymphomatoid papulosis and Epidermodysplasia verruciformis.

Here are the top 5 types of genetic skin disorders:

1. Epidermolysis Bullosa (EB):

Epidermolysis bullosa is a genetic skin disorder where the skin is very fragile and blisters easily. The blisters may be mild to severe, causing scarring. There are different types of EB, but the most common type is an epidermolysis bullosa simplex.

The signs and symptoms may vary widely among the affected individuals. People with EB may experience symptoms such as hair loss, blister around the nose and eyes, tooth decay, deformed nails, frequent infections and dehydration.

2. Harlequin Ichthyosis (HI):

Next in the list of top genetic skin disorders comes is Harlequin ichthyosis. It is a rare skin disorder that generally affects the skin of the new born. This causes large and diamond-shaped scales that are separated by deep cracks.

These skin abnormalities affect the shape of the eyelids, mouth, ears, nose, cornea, penis and restrict the motion of the arms and legs. The symptoms vary widely depending on the place at which harlequin ichthyosis occurs in the body. The main symptoms of Harlequin Ichthyosis are scaly skin, dryness of the skin and anatomical changes.

3. Incontinentia Pigmenti (IP):

Incontinentia pigmenti is a rare genetic skin disorder of the X chromosome that may affect many body systems such as skin, nails, hair, teeth and central nervous system. It is an uncommon genetic syndrome that causes skeletal and neurological problems, it manifests during birth and early childhood.

This condition occurs much more often in females than in males. People with IP may experience abnormal bald patches on the head, dental abnormalities, vision problems and severe neurologic complications like paralysis, delayed development, mental disability and muscle spasms.

4. Lymphomatoid Papulosis (LyP):

Nest among the common genetic skin disorders comes is Lymphomatoid papulosis. It is a rare skin disorder that is characterized by the recurrent appearance of small, raised skin lesions that are red to brown in color. This disorder is rare with a prevalence of only 1 to 2 cases per million people in the population.

These types of skin lesions may be itchy and also bleed sometimes. The skin lesions may occur anywhere on the body, but most often appear on the chest, stomach, back, legs and arms. Lesions automatically heal with or without scarring in 2-8 weeks of appearing.

5. Epidermodysplasia Verruciformis (EV):

This is an extremely rare autosomal recessive genetic skin disorder that is hereditary in nature. It leads to uncontrolled HPV infections which in turn cause scaly macules and papules on the hands and feet. It is also associated with a high risk of carcinoma, a type of skin cancer. This disorder develops due to a mutation of chromosome 17.

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