Everything About BK Virus Renal Transplantation

By on February 18, 2014

Had renal transplantation but not aware of BK virus infections or complications that occur after transplantation? If so, get aware of BK virus worries after having renal transplantation. Today, we are going to discuss on BK Virus Renal Transplantation.

History of BK Virus:

BK Virus is from a polyomavirus family. It was first isolated from the urine of kidney transplant recipient. After renal transplant, 10-60 percent of patients excrete the infected virus in their urine.

How BK Virus affects the patient after getting renal transplantation?

BK Virus Renal TransplantationBK Virus continues to exemplify a formidable challenge in renal transplantation. It is one of the most frequent causes of graft loss after kidney transplantation. It is even the primary pathogen affecting the renal allografts.

BK virus nephritis (BKVN) has become an increasing problem which is posing a threat to increasing renal transplant graft survival.

People with this infection are actually asymptomatic. If the patients do appear with any symptoms, they tend to be respiratory infection or fever. These are referred as primary BK virus symptoms.

There is no evidence for how this virus gets transmitted. However, it is known that virus can spread from human to human but not from animal source. It is suggested that this virus may get transmitted via respiratory fluids or urine as infected individuals excrete virus periodically in the urine.

In some renal transplant recipients, the required use of immune-suppressive drugs allows the infected virus to replicate within the graft, a malady known as BK nephropathy.

The onset of nephritis may happen as early as many days of post-transplant to as late as 5 years.It is even associated with ureteral stenosis as well as interstitial nephritis.

Most renal transplant patients with BK virus nephritis manifest with or without renal dysfunction.Occasionally, patients may also report with ureteric obstruction, hydronephrosis and cystitis.

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