5 Most Common Genetic Causes Of Blood Clots

By on January 17, 2014

Very few people are born with a greater tendency to form blood clots, which further keeps them at higher risk of developing blood clots.

A genetic condition is a tendency due to inherited blood-clotting irregularities from their parents. Let us learn about the main possible genetic causes of blood clots.

Factor V(5) Leiden

Factor V is a plug or protein that helps to stop bleeding and prevents blood clots. Factor V (5) Leiden is a most common genetic condition, which is the main cause of forming blood clots.

Most people with Factor V Leiden probably have one normal gene and one affected gene and it is a rare condition having both the genes affected.

Genetic Causes Of Blood ClotsAffected gene characteristically passed down from parents to their off springs. Child cannot turn off factor V thus excessive blood clotting can happen.
Protein C and Protein S Deficiency

Children with protein C and protein S deficiency are at higher risk of getting blood clots. Protein S and protein C work combine in the body to avert blood clots. A child’s risk for forming blood clots increases by 10-20 fold if they are inherited by protein C and protein S deficiency.

Elevated Levels of Clotting Factors

High levels of pro-coagulants including factors VIII, IX, XI, VII, Von Wille brand factor and fibrinogen are greatly associated with increased risk of blood clotting. Particularly, a higher level of FVIII has been shown to be a leading cause of clotting disorder.

Pro-thrombin 20210 Mutations

A specific mutation of pro-thrombingene increases your risk of developing blood clots almost threefold. This gene alteration called pro-thrombin 20210 mutations is associated with increased levels of pro-thrombin and thus increases the risk of blood clotting.

Anti-thrombin Deficiency

Anti-thrombin deficiency is the most common genetic cause for blood clotting. Anti-thrombin is the natural protein used to prevent blood clots in the human body.

People with anti-thrombin deficiency are at higher risk of experiencing blood clots than average risk for blood clots. Abnormal blood clots are usually formed in the veins.

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